主讲人简介：

何川教授毕业于中国科学技术大学应用化学系，1995年进入美国麻省理工学院学习，2002年作为助理教授加入美国芝加哥大学并于2010年成为教授，2014年至今任芝加哥大学讲席教授与霍华德休斯医学研究所研究员。何川教授是“RNA表观遗传学”领域的发起人之一，发现了可逆RNA甲基化及其在基因表达调控中的作用，荣获保罗·马克斯癌症研究奖（2017）与沃尔夫化学奖（2023）。

讲座内容简介：

Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA. Functional studies reveal m6A methylation as a critical mechanism to group transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. I will also present the most recent advance on chromatin and transcription regulation by RNA methylation and demethylation.

报名链接：https://wj.sjtu.edu.cn/q/AkuqoDh4