探索发现 · 学术讲座

生物材料在生物医学工程的研究和应用
Biomimetic materials for biomedical engineering studies and applications

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奚望,2004年本科毕业于中国科学技术大学高分子材料与工程系,2009年于牛津大学化学系获得博士学位,之后在德国莱布尼茨固态物理和材料研究所和马克斯-普朗克智能系统研究所和新加坡国立大学从事研究工作。现为法国国家科学研究中心“玛丽居里学者”(Marie Curie Fellow),主要研究领域包括微納材料加工制作,可穿戴传感器,微流控器件和组织工程学,在Nature Review Materials, Nature Communications, PNAS, Advanced Materials, Nano Letters, ACS Nano等学术期刊上以第一作者或者通讯作者发表SCI论文26篇,同時获得授权国际专利2項。奚望博士的研究在同行中产生一定的影响力获得多次国际奖励和称号,包括法国教育署的“卓越学者”(Prestige Fellow)和欧盟研究理事会的“玛丽居里学者”(Marie Curie Fellow)。

  

 

 

具体阐述利用新型无机柔性纳米薄膜材料和高聚物材料在生物医学领域的探索和应用,特别是在柔性仿生生物支架,微纳器件,微流计芯片等方面。并展望前沿仿生材料在组织工程层面控制活体组织分化,发育和稳态等重要生物过程的应用。

 

 

Communities of epithelial cells communicate through intercellular interactions, allowing them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and cancer metastasis. Each cell in the epithelium is a constitutive energy-consuming agent, which can generate forces and interact with other cells through cell-cell junctions. Forces applied through external stimuli or endogenous cellular events are balanced by the cells within the epithelium, resulting in the adjustment of internal tissue contractile stresses and tissue reorganization. Materials science and microengineering techniques can be combined to create controllable environments to study epithelial movement and mechanics. By modulating the cell-material interface and by applying principles of active matter, key aspects of epithelial dynamics and mechanosensing mechanisms can be investigated. In this talk, we will discuss epithelial tissues as active materials with particular rheological properties and active behaviours at different length scales. We highlight 2D and 3D materials for the study of epithelial dynamics and summarize key methods for the probing of epithelial mechanics. Tissue responses to mechanical stimuli are examined from the molecular level to the tissue level, and the effects of the shape, architecture and stiffness of the microenvironment are discussed.

 

船舶海洋与建筑工程学院